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Tirzepatide may indirectly raise testosterone by driving significant fat loss and improving insulin sensitivity, while TRT directly addresses clinically low testosterone levels

Abraham N, Schroeter KL, Zhu Y, Chan J, Evans N, Kimber MS, Carere J, Zhou T, Seah SYK (2022b) Structure-function characterization of an aldo-keto reductase involved in detoxification of the mycotoxin, deoxynivalenol